BDBM50553791 CHEMBL4743002

SMILES C[C@H]1OCC2(CCN(CC2)c2cnc(Sc3ccnc(N)c3Cl)c(N)n2)[C@@H]1N

InChI Key InChIKey=UCJZOKGUEJUNIO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50553791   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
TBA

Curated by ChEMBL

LigandBDBM50553791(CHEMBL4743002)Copy SMILESCopy InChI

Affinity DataIC50: 17nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
3/25/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
TBA

Curated by ChEMBL

LigandBDBM50553791(CHEMBL4743002)Copy SMILESCopy InChI

Affinity DataIC50: 28nMAssay Description:Allosteric inhibition of human SHP2 in human KYSE-520 cells assessed as reduction in ERK1/2 phosphorylation by fluorescence based assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In Depth
Date in BDB:
3/25/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL