BDBM50553541 CHEMBL4741334::US20230348415, Compound (+-)-90

SMILES COc1ccc(c(OCC2CCN(C2)c2nc(C)cc(n2)C(O)=O)c1)C(F)(F)F

InChI Key InChIKey=UXFGBOATWPPCIQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553541   

TargetRetinol-binding protein(Human)
Columbia University

US Patent
LigandPNGBDBM50553541(CHEMBL4741334 | US20230348415, Compound (+-)-90)
Affinity DataIC50: 3.00E+3nMAssay Description:Compound binding to RBP4 was assessed in the radiometric scintillation proximity (SPA) assay that was previously described (Cioffi, C. L. et al. 2014...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetRetinol-binding protein(Human)
Columbia University

US Patent
LigandPNGBDBM50553541(CHEMBL4741334 | US20230348415, Compound (+-)-90)
Affinity DataIC50: 3.00E+4nMAssay Description:Compound binding to TTR was assessed in the fluorescence polarization assay. The assay measured competitive displacement of the fluorescent probe, FI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTransthyretin(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50553541(CHEMBL4741334 | US20230348415, Compound (+-)-90)
Affinity DataIC50: 3.00E+4nMAssay Description:Displacement of FITC-diclofenac from human plasma derived TTR measured after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetRetinol-binding protein 4(Human)
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50553541(CHEMBL4741334 | US20230348415, Compound (+-)-90)
Affinity DataIC50: 3.00E+3nMAssay Description:Displacement of [3H]-all-trans-retinol from biotinylated human urine derived RBP4 measured after 16 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed