BDBM50553499 CHEMBL4754493

SMILES Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl

InChI Key InChIKey=RVZJFCNYSSUDCU-UHFFFAOYSA-N

Data  7 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50553499   

TargetCyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild-type human full length CDK7 (M1 to L344 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataKd:  4nMAssay Description:Binding affinity to wild-type human full length CDK9 (M1 to F372 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9/Cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CSNK1A1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of CSNK1D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of CSNK1E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 4nMAssay Description:Binding affinity to CDK9 (unknown origin) by KINOMEscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50553499(CHEMBL4754493)
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to CDK7 (unknown origin) by KINOMEscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed