BDBM50553480 CHEMBL4741442

SMILES C[C@H](CO)Nc1c(cnc(n1)Nc2ccc(cc2)S(=O)(=O)N)Br

InChI Key InChIKey=MJIALGDLOLWBRQ-UHFFFAOYSA-N

Data  24 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50553480   

TargetVascular endothelial growth factor receptor 2(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 34nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 85nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 61nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 61nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 85nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCarbonic anhydrase 2(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 514nMAssay Description:Inhibition of recombinant human CA-II using 4-nitrophenylacetate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 50nMAssay Description:Inhibition of GST-tagged recombinant human CDK1/GST-tagged human cyclin B expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 85nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 61nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 85nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 61nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 50nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 514nMAssay Description:Inhibition of human carbonic anhydrase 2 using 4-nitrophenyl acetate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
The People'S Hospital of Xinjiang Uyghur Autonomous Region

Curated by ChEMBL
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 34nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR2 expressed in Sf-9 cells incubated for 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM50553480(CHEMBL4741442)
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged recombinant human CDK2/GST-tagged human cyclin E expressed in Sf-9 cells incubated for 10 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)