BDBM50553256 CHEMBL258632::N-(3-Nitrophenylpyrazole)Curcumin

SMILES COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)n(n2)-c2cccc(c2)[N+]([O-])=O)ccc1O

InChI Key InChIKey=CPOCVIRWKYNKLB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553256   

TargetMicrotubule-associated protein tau(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of amyloid beta 42 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Aveiro

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 1.51E+4nMAssay Description:Inhibition of amyloid beta 40 secretion transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAlpha-synuclein(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50553256(CHEMBL258632 | N-(3-Nitrophenylpyrazole)Curcumin)
Affinity DataIC50: 8.91E+4nMAssay Description:Inhibition of wild type alpha-synuclein aggregation (unknown origin) expressed in Escherichia coli BL21 cells incubated for 30 days by thioflavin T b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed