BDBM50553069 CHEMBL4796649

SMILES NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1cccc2ccccc12)C(=O)Nc1ccccc1C(N)=O

InChI Key InChIKey=WGXWUSMHARTGNE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50553069   

TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50553069(CHEMBL4796649)
Affinity DataIC50: 340nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged NTMT1 (1 to 222 residues) expressed in Escherichia coli BL21-CodonPlus(DE3)-RIL using GPKRIA p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50553069(CHEMBL4796649)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of NTMT1 in human HCT116 cells assessed as decrease in me3-RCC1 level incubated for 3 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50553069(CHEMBL4796649)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NTMT1 in human HT29 cells assessed as decrease in me3-RCC1 level incubated for 3 days by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetN-terminal Xaa-Pro-Lys N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50553069(CHEMBL4796649)
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of NTMT1 (unknown origin) using SPKRIAKRRS(CONH2) peptide as substrate assessed as SAH production incubated for 10 mins in the presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed