BDBM50552748 CHEMBL4784541::US20240067660, Compound 41

SMILES COCCOCC1(COCCOC)N2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@H](C)[C@@H](C)C\C=C1/F

InChI Key InChIKey=PTYADJMYIQFZAF-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552748   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50552748(CHEMBL4784541 | US20240067660, Compound 41)
Affinity DataKi:  0.25nMAssay Description:Inhibition of Terbium-labeled BIM BH3 peptide binding to MCL1 (unknown origin) incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50552748(CHEMBL4784541 | US20240067660, Compound 41)
Affinity DataKi:  0.25nMAssay Description:The following assay and stock buffers were prepared for use in the assay: (a) Stock buffer: 10 mM Tris-HCl, pH=7.5+150 mM NaCl, filtered, sterilized,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2024
Entry Details
Go to US Patent