BDBM50552139 CHEMBL4790706

SMILES COc1ccc2c(ccnc2c1)-c1ccc(O)c(C)c1

InChI Key InChIKey=HNYBTVKYLVLWCB-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50552139   

TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of TLR8 in HEK-Blue hTLR8 assessed as reduction in SEAP production incubated for 20 to 24 hrs by Quanti-Blue assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at R848 stimulated TRL8 overexpressed in HEK293 cells measured after 20 to 24 hrs by SEAP reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TLR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataKd:  21nMAssay Description:Antagonist activity at human TLR8 by Isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montpellier

Curated by ChEMBL
LigandPNGBDBM50552139(CHEMBL4790706)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human TLR8 stably expressed in human HEK-Blue hTLR8 cells incubated for 24 hrs by Quanti-Blue based SEAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed