BDBM50552106 CHEMBL4765132::US20230399314, Reference compound 2

SMILES FC(F)[C@H]1C[C@@H]1c1cc(nnc1Cl)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=PWZVEKUQVINOOS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50552106   

Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552106(CHEMBL4765132 | US20230399314, Reference compound ...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 2 uM AMP as substrate by rapidfire mass spectrom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552106(CHEMBL4765132 | US20230399314, Reference compound ...)
Affinity DataIC50: 16.8nMAssay Description:The test was performed using Tris-MgCl2 buffer containing 25 mM Tris (Biosharp; 77-86-1) and 25 mM MgCl2 (Nanjing Chemical Reagent Co., Ltd.; 7791-18...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2024
Entry Details
Go to US Patent