BDBM50552097 CHEMBL4798999::US20230399314, Reference compound 1

SMILES Cc1nnc(cc1[C@H]1C[C@@H]1C(F)F)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=IQOAJMSCDHFOGX-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50552097   

Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552097(CHEMBL4798999 | US20230399314, Reference compound ...)
Affinity DataEC50:  51nMAssay Description:Inhibition of CD73 in human serum using 13C5-15N5-AMP as substrate preincubated for 60 mins followed by substrate addition and measured after 15 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552097(CHEMBL4798999 | US20230399314, Reference compound ...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 (1 to 547 residues) expressed in HEK293F cells using 2 uM AMP as substrate by rapidfire mass spectrom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
Target5'-nucleotidase(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50552097(CHEMBL4798999 | US20230399314, Reference compound ...)
Affinity DataIC50: 12.5nMAssay Description:The test was performed using Tris-MgCl2 buffer containing 25 mM Tris (Biosharp; 77-86-1) and 25 mM MgCl2 (Nanjing Chemical Reagent Co., Ltd.; 7791-18...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2024
Entry Details
Go to US Patent