BDBM50551357 CHEMBL4783966

SMILES CC[C@H]1CN(C[C@H]1C1C=NC2=CN=C3NC=CC3N12)C(=O)NCC(F)(F)F

InChI Key InChIKey=DJNQPYNEIBMPBA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50551357   

TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551357(CHEMBL4783966)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 catalytic domain (811 to 1103 residues) expressed in Sf9 insect cells using Biotin-TYR2 (Biotin-(Ahx)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551357(CHEMBL4783966)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human C-terminal His6-tagged JAK2 (808 to end residues) expressed in baculovirus infected Sf21 insect cells using Biotin-TY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50551357(CHEMBL4783966)
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human GST-tagged JAK1 catalytic domain (845 to 1142 residues) expressed in Sf9 insect cells using Biotin-TYR2 (Biotin-(Ahx)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed