BDBM50551136 CHEMBL4757320

SMILES CC(C)(C)c1ccc(NC(=O)c2ncn(CC(=O)NCc3ccc4c(N)nccc4c3)n2)cc1

InChI Key InChIKey=XJFNVUPGNZEXOI-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50551136   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged DOT1L (1 to 420 residues) expressed in Escherichia coli BL21 (DE3) using histone as substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 6.14E+4nMAssay Description:Inhibition of recombinant human G9a using histone H3 (1 to 21) as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 7.98E+4nMAssay Description:Inhibition of recombinant human SET7/9 using core histone as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of recombinant human PRMT3 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 1.13E+5nMAssay Description:Inhibition of recombinant human PRMT5 using histone H2A as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 6.15E+4nMAssay Description:Inhibition of recombinant human PRMT7 using GST-GAR as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
University of Michigan Medical School

Curated by ChEMBL
LigandPNGBDBM50551136(CHEMBL4757320)
Affinity DataIC50: 5.36E+4nMAssay Description:Inhibition of recombinant human PRMT8 using histone H4 as substrate by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed