BDBM50550669 CHEMBL4794132

SMILES C[C@H](CN1C[C@H](C)O[C@H](C)C1)Oc1ccc2Sc3c(Cc2c1)cccc3-c1cc(=O)cc(o1)N1CCOCC1

InChI Key InChIKey=FPWSKINOJYCEJK-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50550669   

TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataIC50: 70nMAssay Description:Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataKd:  2nMAssay Description:Binding affinity to human Vps34 expressed in mammalian expression systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ATR in human HeLa cells incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant full-length human VPS34 incubated for 60 mins by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataIC50: 198nMAssay Description:Inhibition of DNA-PK isolated from human HeLa cells assessed as reduction in p53 Ser15 phosphorylation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Chdi Management/Chdi Foundation

Curated by ChEMBL
LigandPNGBDBM50550669(CHEMBL4794132)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full-length human FLAG-tagged ATM assessed as reduction in p53 S15 phosphorylation incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed