BDBM50550630 CHEMBL4780287

SMILES CC(C)(COc1ccc(cc1)-c1cnc(N)c(c1)-c1ccc(Cl)cc1)C(O)=O

InChI Key InChIKey=GRSMVVJJBSUIMU-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50550630   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550630(CHEMBL4780287)Copy SMILESCopy InChI

Affinity DataIC50: 6.5nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
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TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550630(CHEMBL4780287)Copy SMILESCopy InChI

Affinity DataIC50: 470nMAssay Description:Inhibition of MAP4K4 in human GripTite 293 MSR cells assessed as reduction in TRAF2 Ser/Thr phosphorylation incubated for 1.5 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL