BDBM50550599 CHEMBL4740781

SMILES Nc1ncc(cc1-c1ccc(Cl)cc1)-c1cccc(c1)C(O)=O

InChI Key InChIKey=LGCYIFSJNVXNBT-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50550599   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550599(CHEMBL4740781)Copy SMILESCopy InChI

Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant human GST-tagged MAP4K4 catalytic domain (1 to 328 residues) expressed in baculovirus expression system pre-incubated for 3...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50550599(CHEMBL4740781)Copy SMILESCopy InChI

Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of MAP4K4 in human GripTite 293 MSR cells assessed as reduction in TRAF2 Ser/Thr phosphorylation incubated for 1.5 hrs by ELISAMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL