BDBM50550078 CHEMBL4777551

SMILES c1cc(cc(c1)C(F)(F)F)C2(CCC(CC2)N3CCN(CC3)CC4=CNC(=O)C=C4)O

InChI Key InChIKey=HGNRFWCPFKHVCH-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50550078   

TargetTransient receptor potential cation channel subfamily V member 6(Human)
University of Bern

Curated by ChEMBL

LigandBDBM50550078(CHEMBL4777551)Copy SMILESCopy InChI

Affinity DataIC50: 82nMAssay Description:Inhibition of human TRPV6 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy Entry DOIPubMedPDB3D Structure (crystal)
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TargetTransient receptor potential cation channel subfamily V member 5(Human)
University of Bern

Curated by ChEMBL

LigandBDBM50550078(CHEMBL4777551)Copy SMILESCopy InChI

Affinity DataIC50: 560nMAssay Description:Inhibition of human TRPV5 expressed in HEK293 cells assessed as reduction in Cd2+ influx by calcium-5 fluorescence dye-based FLIPR assayMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
3/23/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL