BDBM50548981 CHEMBL4790354::US20230303494, Compound 11

SMILES COc1cc(NCc2cccc(c2C)-c2ccccc2)c(Cl)cc1CN[C@H](CO)C(O)=O

InChI Key InChIKey=KJAYFOIXDVKLQN-UHFFFAOYSA-N

Data  2 IC50  1 Kd  1 Koff

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548981   

TargetProgrammed cell death 1 ligand 1(Human)
National Engineering Research Center For The Emergency Drug

Curated by ChEMBL
LigandPNGBDBM50548981(CHEMBL4790354 | US20230303494, Compound 11)
Affinity DataKon:  0.000664M-1s-1Assay Description:Binding affinity to biotinylated human AVI-PD-L1 assessed as dissociation constant by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
National Engineering Research Center For The Emergency Drug

Curated by ChEMBL
LigandPNGBDBM50548981(CHEMBL4790354 | US20230303494, Compound 11)
Affinity DataIC50: 107nMAssay Description:Inhibition of PD1-Tag2/PD-L1-Tag1 (unknown origin) protein-protein interaction preincubated for 15 mins followed by addition of anti-Tag1-Eu3+ and an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
National Engineering Research Center For The Emergency Drug

Curated by ChEMBL
LigandPNGBDBM50548981(CHEMBL4790354 | US20230303494, Compound 11)
Affinity DataIC50: 107nMAssay Description:Example 39: The experimental method and procedure were carried out in accordance with the kit instructions, which were briefly described as follows: ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent

TargetProgrammed cell death 1 ligand/protein 1(Human)
National Engineering Research Center For The Emergency Drug

Curated by ChEMBL
LigandPNGBDBM50548981(CHEMBL4790354 | US20230303494, Compound 11)
Affinity DataKd:  0.515nMAssay Description:Example 40: In the experiment, the instrument OctectRED of Fortebio Company based on biofilm interferometry (BLI) technology was used to capture huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent