BDBM50548593 CHEMBL4754247

SMILES Nc1nc(nn1C(=O)c1ccc2ccccc2c1)-c1ccccn1

InChI Key InChIKey=LOMJHEAYYYPWDO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50548593   

TargetProthrombin(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 27nMAssay Description:Inhibition of human coagulation factor alpha-thrombin using Boc-Val-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 138nMAssay Description:Inhibition of human coagulation factor XIIA using Boc-Gln-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human kallikrein using Mes-dArg-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetPlasminogen(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human plasmin using Mes-dArg-Phe-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of FAAH in rat brain membrane using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate measured after 60 mins by reverse-phase HPLC-ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant MAGL using 1,3-dihydroxypropan-2-yl 4-pyren-1-ylbutanoate as substrate measured after 45 mins by reverse-phase HPLC-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human coagulation factor XIA using Mes-dArg-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
University of M£Nster

Curated by ChEMBL
LigandPNGBDBM50548593(CHEMBL4754247)
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of human uPA using Tos-Gly-Pro-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed