BDBM50548013 CHEMBL4745502

SMILES CCn1c(nc2c(ncnc12)-c1cnc2NC(=O)[C@@](C)(N3CC(C)(C3)OC)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=PDSQZLIADJZUSV-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548013   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50548013(CHEMBL4745502)Copy SMILESCopy InChI

Affinity DataIC50: 3.90nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50548013(CHEMBL4745502)Copy SMILESCopy InChI

Affinity DataIC50: 180nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-induced AKT phosphorylation at Ser473 residue preincubated for 20 mins...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL