BDBM50548010 CHEMBL4800086

SMILES [H][C@@]1(CCOC1)N[C@]1(C)C(=O)Nc2ncc(cc12)-c1ncnc2n(C)c(nc12)-c1cnc(C)nc1

InChI Key InChIKey=KOJUGTUREQCBQO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548010   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50548010(CHEMBL4800086)Copy SMILESCopy InChI

Affinity DataIC50: 4.40nMAssay Description:Inhibition of N-terminal His6 tagged recombinant full-length human PI3Kdelta/human recombinant full-length p85alpha expressed in baculovirus infected...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck

Curated by ChEMBL

LigandBDBM50548010(CHEMBL4800086)Copy SMILESCopy InChI

Affinity DataIC50: 320nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-induced AKT phosphorylation at Ser473 residue preincubated for 20 mins...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/22/2022
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL