BDBM50547928 CHEMBL4787299

SMILES COc1c(Oc2cc(c(OC)c(F)c2C(=O)Nc2ccnc(c2)C(N)=O)C(F)(F)F)ccc(OC(F)(F)F)c1F

InChI Key InChIKey=APHKKFMONQEXNB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547928   

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547928(CHEMBL4787299 | US12441703, Compound 325)
Affinity DataIC50: 1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2026
Entry Details US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547928(CHEMBL4787299 | US12441703, Compound 325)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human Nav1.8 expressed in HEK cells applied electrical stimulus 10 Hz for 10 seconds measuring relaxation to the resting state followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed