BDBM50547876 CHEMBL4791770::US20230271945, Compound 20

SMILES Fc1cc(F)c2[nH]c(c(CCC(=O)N[C@H]3CCNC3=O)c2c1)-c1ccc(cc1)C#N

InChI Key InChIKey=WJPMVVYPNLGJLY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50547876   

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50: 600nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50: 600nMAssay Description:Briefly, the AlamarBlue active compound, the resazurin, a blue, water soluble, non-toxic and cell permeable molecule, which can be followed by absorb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
Go to US Patent

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM50547876(CHEMBL4791770 | US20230271945, Compound 20)
Affinity DataIC50: 250nMAssay Description:Inhibition of APOL1 (unknown origin) in HEK293 cells assessed as thallium influx incubated for 30 mins by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed