BDBM50547648 CHEMBL4800349

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)C#CC#Cc1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)c1ccccc1

InChI Key InChIKey=QCTQJCIBXHOVHQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50547648   

TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of HCV genotype 5a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 10.7nMAssay Description:Inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 0.423nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 0.758nMAssay Description:Inhibition of HCV genotype 1a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 0.0120nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547648(CHEMBL4800349)
Affinity DataIC50: 0.431nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed