BDBM50547630 CHEMBL4758660

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(C#CC#Cc2cnc([nH]2)[C@@H]2CCCN2C(=O)[C@H](NC(=O)OC)c2ccccc2)c(c1)-c1cccc(c1)C(C)(C)C

InChI Key InChIKey=UGCPIFAZUREOTQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50547630   

TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 0.107nMAssay Description:Inhibition of HCV genotype 5a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 0.0930nMAssay Description:Inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 1.07nMAssay Description:Inhibition of HCV genotype 1a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50: 0.104nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed