BDBM50546500 CHEMBL4750308

SMILES COc1ccc(cc1)S(=O)(=O)N1CCC[C@@H]1C(=O)NO

InChI Key InChIKey=FRNDBEYBKGOTNX-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50546500   

Target72 kDa type IV collagenase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-Lys-Pro-Leu-GlyLeu-Dpa-Ala-Arg-NH2 as substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataIC50: 22nMAssay Description:Inhibition of MMP9 (unknown origin) using Mca-Lys-Pro-Leu-GlyLeu-Dpa-Ala-Arg-NH2 as substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataKi:  8.10nMAssay Description:Inhibition of MMP2 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 5 min followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP9 (unknown origin) using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 5 min followed by substrate addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human CA1 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50546500(CHEMBL4750308)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration kinetic assay based Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed