BDBM50546436 CHEMBL4799793

SMILES Clc1ccc-2c(CCCc3nnc([C@H]4CC[C@@H](CC4)Oc4ccccn4)n-23)c1

InChI Key InChIKey=XPJLLCAORNNZCL-UHFFFAOYSA-N

Data  6 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50546436   

TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataIC50: 1nMAssay Description:Inhibition of human V1a receptor expressed in human 1321N1 cells assessed as decrease in Arg8-vasopressin-stimulated calcium flux by fluorometric cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human ERG by QPatch HTX automated patch clamp systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataIC50: 1nMAssay Description:Inhibition of human V1A receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescent plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V1A receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity against human V1A receptor expressed in human 1321N1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetVasopressin V1a receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetVasopressin V2 receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]AVP from human V2a receptor expressed in 1132N1 cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetVasopressin V2 receptor(Human)
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50546436(CHEMBL4799793)
Affinity DataKi:  560nMAssay Description:Displacement of [3H]-arginine-vasopressin from human V2 receptor expressed in human 1321N1 cell membranes incubated for 60 mins by radioligand bindin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed