BDBM50546243 CHEMBL4753864

SMILES [H][C@]12C[C@@]1([H])N([C@@H](C2)C(=O)N[C@@H](C)c1cccc(Cl)c1F)C(=O)Cn1nc(C(N)=O)c2cccnc12

InChI Key InChIKey=SOXWMGIJZSBBEW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50546243   

TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 70nMAssay Description:Inhibition of CFD in human RBC model of anti-CD55/anti-CD59-induced paroxysmal nocturnal hemoglobinuria assessed as reduction in complement fragment ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 6nMAssay Description:Inhibition of CFD in 10% human serum assessed as reduction in alternate complement pathway-mediated hemolysis incubated for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetComplement factor D(Human)
Taipei Medical University

Curated by ChEMBL
LigandPNGBDBM50546243(CHEMBL4753864)
Affinity DataIC50: 140nMAssay Description:Inhibition of CFD in 50% human whole blood assessed as reduction in alternate complement pathway-mediated MAC formation pre-incubated for 15 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed