BDBM50545932 CHEMBL4759670

SMILES Cc1cc(cn(C)c1=O)-c1ccc2nc(nc(N3CCOC[C@@H]3C3CC3)c2c1)-c1cnn(CC(C)(C)O)c1

InChI Key InChIKey=ABZCGQSUBXIYHN-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50545932   

TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545932(CHEMBL4759670)
Affinity DataKd:  70nMAssay Description:Competitive binding affinity to human partial length BRD4 (BD1,2) (N44 to E460 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545932(CHEMBL4759670)
Affinity DataKd: <100nMAssay Description:Binding affinity to DNA-tagged human BRD4 (BD1,2) isoform long expressed in Escherichia coli BL21 incubated for 1 hr by competitive ligand binding BR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545932(CHEMBL4759670)
Affinity DataIC50: 100nMAssay Description:Inhibition of binding of N-terminal His-tagged human full length recombinant BRD4 (2 to 1362 residues) expressed in baculovirus-infected Sf9 cells wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed