BDBM50545931 CHEMBL4741110

SMILES Cn1cc(ccc1=O)-c1ccc2nc(nc(N3CCOC[C@@H]3c3cccs3)c2c1)-c1cnn(CC(C)(C)O)c1

InChI Key InChIKey=LUBQVUAOCSCIIB-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50545931   

TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545931(CHEMBL4741110)
Affinity DataIC50: 165nMAssay Description:Inhibition of human full-length recombinant N-terminal His-tagged BRD4 (2 to 1362 residues) expressed in Sf9 cells using histone H4 peptide containin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50545931(CHEMBL4741110)
Affinity DataKd:  300nMAssay Description:Competitive binding affinity to human partial length BRD4 (BD1,2) (N44 to E460 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed