BDBM50545575 CHEMBL4648967::US11530193, Example 3

SMILES CC(C)(C)c1cc(Nc2nc(ncc2C(N)=O)N2CCC[C@H](N)C2)cc(c1)C(C)(C)C

InChI Key InChIKey=CZRHQTSOTFWKCN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50545575   

TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545575(CHEMBL4648967 | US11530193, Example 3)
Affinity DataIC50: 399nMAssay Description:Inhibition of human CAMK1D using KKALRRQETVDAL as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 5(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545575(CHEMBL4648967 | US11530193, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MEK5 using ERK5 as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545575(CHEMBL4648967 | US11530193, Example 3)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MLK3 using myelin basic protein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1D(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50545575(CHEMBL4648967 | US11530193, Example 3)
Affinity DataIC50: 429nMAssay Description:The following describes an ADP-Glo Kinase Assay, which measures the ADP formed from a kinase reaction; the ADP generated is converted into ATP and is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2023
Entry Details
Go to US Patent