BDBM50545296 CHEMBL4639434

SMILES Cc1cc(C)c2[nH]c(Nc3cc(ccc3-c3ccsc3)S(=O)(=O)NC3CC3)nc2c1

InChI Key InChIKey=YSMGSTZYRIWGHK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50545296   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132C mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 960nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of wild type IDH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Shandong Provincial Hospital Affiliated To Shandong University

Curated by ChEMBL
LigandPNGBDBM50545296(CHEMBL4639434)
Affinity DataIC50: 5.18E+4nMAssay Description:Inhibition of IDH2 R172K mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed