BDBM50545085 CHEMBL4643590

SMILES [H][C@]1(Cc2ccc(OCCCC(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N1)cc2)C(=O)N[C@@H](CCCCNC(C)=S)C(=O)N[C@@]1([H])Cc2ccc(OCCCCCNC(=O)[C@H](CCSC)NC1=O)cc2

InChI Key InChIKey=ZBRJJUKVURYJIL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50545085   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 540nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 253nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 720nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 4.43E+5nMAssay Description:Inhibition of His6-tagged human SIRT5 desuccinylation activity using succinyl-lysine as substrate in presence of beta-NAD+ after 5 mins by reversed-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of His6-tagged human SIRT6 demyristoylation activity using myristoyl-lysine substrate in presence of beta-NAD+ after 12 mins by reversed-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 7.89E+4nMAssay Description:Inhibition of tRNA-activated His6-tagged human SIRT7 deacetylation activity using acetyl-lysine as substrate in presence of beta-NAD+ after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed