BDBM50544959 CHEMBL4635873::US12122742, Compound II-a-2

SMILES OC(=O)CN(Cc1ccccc1CN(CC(O)=O)S(=O)(=O)c1ccc(OCc2ccccc2)cc1)S(=O)(=O)c1ccc(OCc2ccccc2)cc1

InChI Key InChIKey=UGKMAGZZCXCLML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50544959   

TargetKelch-like ECH-associated protein 1(Human)
The State University of New Jersey

Curated by ChEMBL
LigandPNGBDBM50544959(CHEMBL4635873 | US12122742, Compound II-a-2)
Affinity DataIC50: 570nMAssay Description:Inhibition of FITC-LDEETGEFL-NH2 binding to recombinant human Keap1 Kelch domain (321 to 609 residues) expressed in Escherichia Coli BL21(DE3)pLysS c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2(Human)
Rutgers, The State University of New Jersey

US Patent
LigandPNGBDBM50544959(CHEMBL4635873 | US12122742, Compound II-a-2)
Affinity DataIC50: 0.260nMAssay Description:Fluorescence polarization assay was performed on a Wallac Victor 3V multi-label counter/plate reader (PerkinElmer, Shelton, CT) using 484 nm excitati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2025
Entry Details
Go to US Patent