BDBM50544785 CHEMBL4645258

SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CCNC(=O)COC2)n3)c1

InChI Key InChIKey=VHPOHFDPEQHMMX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50544785   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50544785(CHEMBL4645258)
Affinity DataIC50: 23nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50544785(CHEMBL4645258)
Affinity DataIC50: 910nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50544785(CHEMBL4645258)
Affinity DataIC50: 180nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50544785(CHEMBL4645258)
Affinity DataIC50: 130nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50544785(CHEMBL4645258)
Affinity DataIC50: 210nMAssay Description:Inhibition of TYK2 in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed