BDBM50544756 CHEMBL4637350

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(C)CC2)cc1

InChI Key InChIKey=KBQYYXDCPRZITN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50544756   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 39nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of EZH2 A677G mutant (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sichuan University and Collaborative Innovation Center

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 39nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin) by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Affiliated Hospital of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM50544756(CHEMBL4637350)
Affinity DataIC50: 84nMAssay Description:Inhibition of wild-type EZH1 (unknown origin) by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed