BDBM50544724 CHEMBL4641469

SMILES COc1cccc(OC)c1-c1cc(nn1C1CCCC1)C(=O)N[C@@H](CCC1CCCCC1)CC(O)=O

InChI Key InChIKey=XYGKCMALHVTDPX-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50544724   

TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  2.47E+3nMAssay Description:Agonist activity at human APJ receptor stably expressed in CHOK1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  424nMAssay Description:Agonist activity at human APJ receptor stably expressed in CHO cells co-expressing Galphaq16 assessed as increase in intracellular calcium mobilizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  238nMAssay Description:Agonist activity at human APJ receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  238nMAssay Description:Agonist activity at human APJ receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 40 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  2.47E+3nMAssay Description:Agonist activity at human AGTRL1 expressed in CHO-K1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by PathHunter a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetApelin receptor(Human)
Rti International

Curated by ChEMBL
LigandPNGBDBM50544724(CHEMBL4641469)
Affinity DataEC50:  424nMAssay Description:Agonist activity at Galphaq16-fused human APJ receptor expressed in CHO cells assessed as stimulation of Ca2+ mobilization incubated for 1 hr by Calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed