BDBM50544707 CHEBI:72754::CHEMBL1900054

SMILES c1cc(ccc1C(c2ccc(cc2)O)(C(F)(F)F)C(F)(F)F)O

InChI Key InChIKey=ZFVMWEVVKGLCIJ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50544707   

TargetEstrogen receptor(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50: 40nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor beta(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataEC50:  20nMAssay Description:Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor beta(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50: 70nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed