BDBM50544398 CHEMBL4635902

SMILES COc1cc(cc(OC)c1OC)-c1cncc(-c2ccc(cc2)N2CCNCC2)c1C(F)(F)F

InChI Key InChIKey=GZYSDVXZHBPWRC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50544398   

TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544398(CHEMBL4635902)
Affinity DataIC50: 67nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544398(CHEMBL4635902)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544398(CHEMBL4635902)
Affinity DataIC50: 184nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544398(CHEMBL4635902)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed