BDBM50544396 CHEMBL4633121

SMILES COc1cc(cc(OC)c1OC)-c1cncc(c1F)-c1ccc(cc1)N1CCNCC1

InChI Key InChIKey=NYYYLFUSXWJOML-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50544396   

TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544396(CHEMBL4633121)
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544396(CHEMBL4633121)
Affinity DataIC50: 880nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544396(CHEMBL4633121)
Affinity DataIC50: 32nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544396(CHEMBL4633121)
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Ontario Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50544396(CHEMBL4633121)
Affinity DataIC50: 630nMAssay Description:Inhibition of human ALK4 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed