BDBM50544198 CHEMBL4636136

SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=DWDATRBHPMAHRD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544198   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544198(CHEMBL4636136)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544198(CHEMBL4636136)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544198(CHEMBL4636136)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed