BDBM50543599 CHEMBL4640376

SMILES CNC(=O)c1ccc(cn1)-c1c(C)nc2c(OCc3ccc(cc3F)-c3ccc(F)cc3)cccn12

InChI Key InChIKey=BYNYKLMQYRNKAJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50543599   

TargetPresenilin-1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)
Affinity DataIC50: 29nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2 assessed as reduction in metabolite formation using CEC as substrate incubated for 20 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C9 assessed as reduction in metabolite formation using MFC as substrate incubated for 30 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19 assessed as reduction in metabolite formation using CEC as substrate incubated for 20 mins by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543599(CHEMBL4640376)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 assessed as reduction in metabolite formation using AMMC as substrate incubated for 20 mins by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed