BDBM50543593 CHEMBL4645370

SMILES CCn1oc2cc(ccc2c1=O)-c1c(C)nc2c(OCc3ccc(cc3)-c3ccc(F)cc3)cccn12

InChI Key InChIKey=ZKSBQNSMYSOSNT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50543593   

TargetPresenilin-1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543593(CHEMBL4645370)
Affinity DataIC50: 90nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed