BDBM50543591 CHEMBL4640988

SMILES CCNC(=O)c1ccc(cn1)-c1c(C)nc2c(OCc3ccc(cc3)-c3ccccc3C(F)(F)F)cccn12

InChI Key InChIKey=KALFQKWWQNEOTH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50543591   

TargetPresenilin-1(Human)
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50543591(CHEMBL4640988)
Affinity DataIC50: 180nMAssay Description:Inhibition of gamma-secretase in human SK-N-BE cells assessed as decrease in amyloid beta 42 production treated for 6 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed