BDBM50543383 CHEMBL4634904

SMILES CC(C)(C)c1cc2c(c(c1)F)C(=O)N(N=C2)c3c(c(ccn3)C4=CN(C(=O)C(=C4)NC(=O)[C@@H]5C[C@@H]5F)C)CO

InChI Key InChIKey=SEGFWFQHVPYNMS-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50543383   

TargetTyrosine-protein kinase BTK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50543383(CHEMBL4634904)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in autophosphorylation at Y223 residue incubated for 1 hr by mesoscale assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50543383(CHEMBL4634904)
Affinity DataIC50: 78nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-IgM-stimulated CD69 expression preincubated for 1 hr followed by goat F(ab')2 an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50543383(CHEMBL4634904)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human ERG by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 4B1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50543383(CHEMBL4634904)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human liver microsome CYP450More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed