BDBM50543380 CHEMBL4649410

SMILES Cn1cc(cc(NC(=O)C2CC2)c1=O)-c1ccnc(c1CO)-n1ncc2c3CCCCc3sc2c1=O

InChI Key InChIKey=UMTUMIVHMIKPOR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50543380   

TargetTyrosine-protein kinase BTK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50543380(CHEMBL4649410)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in autophosphorylation at Y223 residue incubated for 1 hr by mesoscale assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50543380(CHEMBL4649410)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in anti-IgM-stimulated CD69 expression preincubated for 1 hr followed by goat F(ab')2 an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed