BDBM50543133 CHEMBL4649550

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(C)no1)[C@H]2Nc1nc2c(OCC(F)(F)F)ccc(n2n1)C(F)(F)F

InChI Key InChIKey=CXJQWJBRXYDTFP-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50543133   

TargetPresenilin-1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50543133(CHEMBL4649550)
Affinity DataIC50: 33nMAssay Description:Modulation of gamma secretase in human H4 cells over expressing human APP695 harboring K595N/M596L Swedish double mutant assessed as reduction in Abe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50543133(CHEMBL4649550)
Affinity DataIC50: 8.75E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50543133(CHEMBL4649550)
Affinity DataKd: >4.00E+4nMAssay Description:Binding affinity to PIK4CB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNeurogenic locus notch homolog protein 1(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50543133(CHEMBL4649550)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Notch1 expressed in HEK293 cells coexpressing luciferase reporter measured after 20 hrs by steady-glo chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed