BDBM50542999 CHEMBL4648876

SMILES NCCN1CCN(Cc2cc(ccc2Oc2ccc(F)c(Cl)c2)S(N)(=O)=O)CC1

InChI Key InChIKey=TVIGXEOVBNMTRW-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50542999   

TargetSon of sevenless homolog 1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50542999(CHEMBL4648876)
Affinity DataKd:  1.65E+4nMAssay Description:Displacement of FITC-labelled probe from human SOS1 catalytic domain (564 to 1049 residues) incubated for 20 mins by fluorescence polarization compet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSon of sevenless homolog 1(Human)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50542999(CHEMBL4648876)
Affinity DataEC50:  1.63E+4nMAssay Description:Agonist activity at His6-tagged-human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli BL21-CodonPlus-RIPL cells assessed a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed