BDBM50542976 CHEMBL4636606::US11535615, Example 1

SMILES Cc1c(Nc2cccc3cc(CNCCO)cnc23)cccc1-c1ccccc1

InChI Key InChIKey=NHGZPWFRCNWOMB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50542976   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542976(CHEMBL4636606 | US11535615, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 resid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50542976(CHEMBL4636606 | US11535615, Example 1)
Affinity DataIC50: 55nMAssay Description:The assays were conducted in a standard black 384-well polystyrene plate with a final volume of 20 μL. Inhibitors were first serially diluted in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2023
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542976(CHEMBL4636606 | US11535615, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed