BDBM50542954 CHEMBL4639202

SMILES Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CNC(C)(C)C(O)=O)cc2Cl)cccc1-c1ccccc1

InChI Key InChIKey=YZPKZNFXWGTUGO-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50542954   

TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542954(CHEMBL4639202)
Affinity DataIC50: 13nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542954(CHEMBL4639202)
Affinity DataIC50: 13nMAssay Description:Inhibition of human C-terminal Ig-Fc-tagged PD1 (Leu25 to Gln167 residues) expressed in HEK293 cells/human C-terminal epitope-His-tagged PDL1 (Phe19 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542954(CHEMBL4639202)
Affinity DataEC50:  3.00E+3nMAssay Description:Inhibition of human PD1/PDL1 protein-protein interaction in human PBMC-derived CD3-positive T cells co-cultured with human Hep3B cells expressing hum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetProgrammed cell death 1 ligand/protein 1(Mouse)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50542954(CHEMBL4639202)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse biotin-labelled C-terminal Fc-fused/Avi-tagged PD1/Fc-fused PDL1 expressed in HEK293 cells protein-protein interaction measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed