BDBM50542216 CHEMBL4642047

SMILES CCN(C(=O)c1cc(cc(c1)C(C)(C)C)C(C)(C)C)c1ccc(cc1)C(=O)NO

InChI Key InChIKey=TXCJJCXDRMEQEN-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50542216   

TargetHistone deacetylase 3(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal His-tagged and N-terminal GST-tagged full length human HDAC3 expressed in baculovirus expression system co-expressed with hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of C-terminal FLAG-tagged full length human HDAC6 expressed in baculovirus expression system using FAM-RHKK(Ac)-NH2 substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataIC50: 80nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC8 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of N-terminal His-tagged full length human HDAC11 expressed in baculovirus expression system using FAM-RHKK(TF-Ac)-NH2 substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataKd:  95nMAssay Description:Binding affinity to His-tagged recombinant human HDAC8 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Toronto Mississauga

Curated by ChEMBL
LigandPNGBDBM50542216(CHEMBL4642047)
Affinity DataIC50: 108nMAssay Description:Binding affinity to human HDAC8 pre-incubated for 10 mins before FITC-M344 addition and measured after 10 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed